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1.
Comput Biol Med ; 174: 108429, 2024 Apr 11.
Artigo em Inglês | MEDLINE | ID: mdl-38631116

RESUMO

In this research work, a novel fuzzy data transformation technique has been proposed and applied to the hormonal imbalance dataset. Hormonal imbalance is ubiquitously found principally in females of reproductive age which ultimately leads to numerous related medical conditions. Polycystic Ovary Syndrome (PCOS) is one of them. Treatment along with adopting a healthy lifestyle is advised to mitigate its consequences on the quality of life. The biological dataset of hormonal imbalance "PCOS" provides limited results that is whether the syndrome is present or not. Also, there are input variables that contain binary responses only, to deal with this conundrum, a novel fuzzy data transformation technique has been developed and applied to them thus leading to their fuzzy transformation which provides a broader spectrum to diagnose PCOS. Due to this, the output variable has also been transformed. Hence, a novel fuzzy transformation technique has been employed due to the limitation of the dataset leading to the transition of binary classification output into three classes. An adaptive fuzzy machine learning logic model is developed in which the inference of the transformed biological dataset is performed by the machine learning techniques that provide the fuzzy output. Machine learning techniques have also been applied to the untransformed biological dataset. Both implementations have been compared by computation of the relevant metrics. Machine learning employment on untransformed biological dataset provides limited results whether the syndrome is present or absent however machine learning on fuzzy transformed biological dataset provides a broader spectrum of diagnosis consisting of a third class depicting that PCOS might be present which would ultimately alert a patient to take preventive measures to minimize the chances of syndrome development in future.

2.
Heliyon ; 10(6): e27796, 2024 Mar 30.
Artigo em Inglês | MEDLINE | ID: mdl-38560663

RESUMO

The paper establishes the effective utilization of North American Electric Reliability Corporation control performance standards for cascaded fractional order controller in dispensing regulation ancillary service to the deregulated structures having intermittent generating units. The flow resources that highly contribute in faster regulatory facility include photovoltaic and wind systems. For a two area network, the control performance standard 1and balancing authority ACE limits, the successor to CPS2 are assumed to be the control inputs to the fuzzy logic base and its tuned output gain is fed to the cascaded proportional-integral-derivative double staged FOPID controller for best fallouts in dynamic stability and frequency response leveraged under diverse market contracts. Reduced depletion and depreciation in the generating unit equipment by restricted operation of the turbine valves in accordance to the generation load mismatch is the foremost virtue of the suggested performance metrics. The concurrent feed of the above mentioned standards to the fuzzy logic base against varying disturbances, contrary to thermal constraints in iterative sequence, grades to uniform reliability and consistent generation-load balance. The effectiveness of the suggested controller is verified in MATLAB forum against existing classical, cascaded and intelligent centered FO controllers manifested with artificial hummingbird algorithm owing to its proven supremacy and robustness in literature. The analytical effects in transient mode of operation is evaluated with integral time absolute error as fitness function as it epitomizes the reduction of larger errors at the initial and longer transient response state.

3.
BMC Med Imaging ; 24(1): 86, 2024 Apr 10.
Artigo em Inglês | MEDLINE | ID: mdl-38600525

RESUMO

Medical imaging AI systems and big data analytics have attracted much attention from researchers of industry and academia. The application of medical imaging AI systems and big data analytics play an important role in the technology of content based remote sensing (CBRS) development. Environmental data, information, and analysis have been produced promptly using remote sensing (RS). The method for creating a useful digital map from an image data set is called image information extraction. Image information extraction depends on target recognition (shape and color). For low-level image attributes like texture, Classifier-based Retrieval(CR) techniques are ineffective since they categorize the input images and only return images from the determined classes of RS. The issues mentioned earlier cannot be handled by the existing expertise based on a keyword/metadata remote sensing data service model. To get over these restrictions, Fuzzy Class Membership-based Image Extraction (FCMIE), a technology developed for Content-Based Remote Sensing (CBRS), is suggested. The compensation fuzzy neural network (CFNN) is used to calculate the category label and fuzzy category membership of the query image. Use a basic and balanced weighted distance metric. Feature information extraction (FIE) enhances remote sensing image processing and autonomous information retrieval of visual content based on time-frequency meaning, such as color, texture and shape attributes of images. Hierarchical nested structure and cyclic similarity measure produce faster queries when searching. The experiment's findings indicate that applying the proposed model can have favorable outcomes for assessment measures, including Ratio of Coverage, average means precision, recall, and efficiency retrieval that are attained more effectively than the existing CR model. In the areas of feature tracking, climate forecasting, background noise reduction, and simulating nonlinear functional behaviors, CFNN has a wide range of RS applications. The proposed method CFNN-FCMIE achieves a minimum range of 4-5% for all three feature vectors, sample mean and comparison precision-recall ratio, which gives better results than the existing classifier-based retrieval model. This work provides an important reference for medical imaging artificial intelligence system and big data analysis.


Assuntos
Inteligência Artificial , Tecnologia de Sensoriamento Remoto , Humanos , Ciência de Dados , Armazenamento e Recuperação da Informação , Redes Neurais de Computação
4.
ISA Trans ; 2024 Mar 26.
Artigo em Inglês | MEDLINE | ID: mdl-38599929

RESUMO

Wind turbines (WTs) have highly nonlinear and uncertain dynamics due to aerodynamic complexity, mechanical factors, and fluctuations in wind conditions. Turbulence and wind shear add complexity to modelling, especially in constant power region (region 3). Thus, an effective control design demands a deep understanding of the nonlinearities and uncertainties. This paper suggests a novel model-free reinforcement learning (RL) collective pitch angle controller to operate efficiently in region 3. The proposed controller stabilizes generator speed, maximizes power output, and minimizes fluctuations while accommodating system uncertainties, nonlinearity, and pitch limits. The disparity between WT dynamics due to wind speed perturbations and uncertainties is measured using a gap-metric criterion. The controller design adopts a deep deterministic policy gradient (DDPG) algorithm to train six agents in a medium-fidelity WT environment at different mean wind speeds to ensure the controller's robustness. Initially, imitation learning is used for efficient sample collection to fasten training convergence. Afterwards, the agent learns by interacting with the environment. After the training, the pitch control outputs from multi-trained agents are processed by a fuzzy system to have smooth transitions under different operating conditions. The resulting fuzzy DDPG (F-DDPG) controller is deployed to obtain the optimal pitch control action. The performance of the proposed F-DDPG controller is compared to the gain-scheduled PI (GSPI), Linear-Quadratic-Regulator (LQR), and single-DDPG-agent controllers. The controllers are simulated in high-fidelity onshore and offshore 5-MW WT environments using the OpenFAST/MATLAB simulation tools. The results reveal the superiority of the proposed controller in generalizing its optimal performance in different operating conditions.

5.
Ying Yong Sheng Tai Xue Bao ; 35(2): 354-362, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38523092

RESUMO

Forest fires have a significant impact on human life, property safety, and ecological environment. Deve-loping high-quality forest fire risk maps is beneficial for preventing forest fires, guiding resource allocation for firefighting, assisting in fire suppression efforts, and supporting decision-making. With a multi-criteria decision analysis (MCDA) method based on geographic information systems (GIS) and literature review, we assessed the main factors influencing the occurrences of forest fires in Youxi County, Fujian Province. We analyzed the importance of each fire risk factor using the analytic network process (ANP) and assigned weights, and evaluated the sub-standard weights using fuzzy logic assessment. Using ArcGIS aggregation functions, we generated a forest fire risk map and validated it with satellite fire points. The results showed that the areas classified as level 4 or higher fire risk accounted for a considerable proportion in Youxi County, and that the central and northern regions were at higher risk. The overall fire risk situation in the county was severe. The fuzzy ANP model demonstrated a high accuracy of 85.8%. The introduction of this novel MCDA method could effectively improve the accuracy of forest fire risk mapping at a small scale, providing a basis for early fire warning and the planning and allocation of firefighting resources.


Assuntos
Lógica Fuzzy , Incêndios Florestais , Humanos , Incêndios/prevenção & controle , Florestas , Sistemas de Informação Geográfica , Árvores , Incêndios Florestais/estatística & dados numéricos
6.
Sensors (Basel) ; 24(5)2024 Feb 28.
Artigo em Inglês | MEDLINE | ID: mdl-38475087

RESUMO

In smart cities, bicycle-sharing systems have become an essential component of the transportation services available in major urban centers around the globe. Due to environmental sustainability, research on the power-assisted control of electric bikes has attracted much attention. Recently, fuzzy logic controllers (FLCs) have been successfully applied to such systems. However, most existing FLC approaches have a fixed fuzzy rule base and cannot adapt to environmental changes, such as different riders and roads. In this paper, a modified FLC, named self-tuning FLC (STFLC), is proposed for power-assisted bicycles. In addition to a typical FLC, the presented scheme adds a rule-tuning module to dynamically adjust the rule base during fuzzy inference processes. Simulation and experimental results indicate that the presented self-tuning module leads to comfortable and safe riding as compared with other approaches. The technique established in this paper is thought to have the potential for broader application in public bicycle-sharing systems utilized by a diverse range of riders.

7.
Accid Anal Prev ; 199: 107529, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38442630

RESUMO

Surrogate Safety Measures (SSM) are extensively applied in safety analysis and design of active vehicle safety systems. However, most existing SSM focus only on the one-dimensional interactions along the vehicle traveling direction and cannot handle the crash risks associated with vehicle lateral movements such as sideswipes and angle crashes. To bridge this important knowledge gap, this study proposes a two-dimensional SSM defined based on Fuzzy Logic and the Inverse Time to Collision (FL-iTTC), which accounts for neighboring vehicles' lateral kinematics and the uncertainty of their movements. The proposed FL-iTTC are proven to be more accurate than traditional SSM in identifying typical risky scenarios, including harsh decelerations, sudden lane-changes, cut-ins and pre-crashes that are extracted from the NGSIM dataset. Additionally, other naturalistic driving scenarios are extracted from the NGSIM dataset and are used to evaluate the effectiveness of different SSM in quantifying crash risks. FL-iTTC is compared with other two-dimensional SSM including Anticipated Collision Time (ACT) and Probabilistic Driving Risk Field (PDRF) based on the confusion matrix and the receiver operating characteristic (ROC) curve. The Area under the ROC Curve (AUC) is 0.923 for FL-iTTC, while only 0.891 for ACT and 0.907 for PDRF, which indicates FL-iTTC outperforms other two-dimensional SSM in risk assessment. Overall, the proposed FL-iTTC greatly complements existing SSM and provides a reliable and useful tool to evaluate various crash risks associated with vehicle lateral movements such as cut-in and sideswipe.


Assuntos
Acidentes de Trânsito , Condução de Veículo , Humanos , Acidentes de Trânsito/prevenção & controle , Lógica Fuzzy , Medição de Risco , Viagem
8.
Front Neurosci ; 18: 1362495, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38440394

RESUMO

The clinical rehabilitation assessment methods for hemiplegic upper limb motor function are often subjective, time-consuming, and non-uniform. This study proposes an automatic rehabilitation assessment method for upper limb motor function based on posture and distributed force measurements. Azure Kinect combined with MediaPipe was used to detect upper limb and hand movements, and the array distributed flexible thin film pressure sensor was employed to measure the distributed force of hand. This allowed for the automated measurement of 30 items within the Fugl-Meyer scale. Feature information was extracted separately from the affected and healthy sides, the feature ratios or deviation were then fed into a single/multiple fuzzy logic assessment model to determine the assessment score of each item. Finally, the total score of the hemiplegic upper limb motor function assessment was derived. Experiments were performed to evaluate the motor function of the subjects' upper extremities. Bland-Altman plots of physician and system scores showed good agreement. The results of the automated assessment system were highly correlated with the clinical Fugl-Meyer total score (r = 0.99, p < 0.001). The experimental results state that this system can automatically assess the motor function of the affected upper limb by measuring the posture and force distribution.

9.
Heliyon ; 10(6): e27798, 2024 Mar 30.
Artigo em Inglês | MEDLINE | ID: mdl-38545231

RESUMO

Edge detection is a vital aspect of medical image processing, playing a key role in delineating borders and contours within images. This capability is instrumental for various applications, including segmentation, feature extraction, and diagnostic procedures in the realm of medical imaging. COVID-19 is a deadly disease affecting people in most of countries in the world. COVID-19 is due to the coronavirus which belongs to the family of RNA viruses and causes various symptoms such as pneumonia, fever, breathing difficulty, and lung infection. ROI extraction plays a vital role in disease diagnosis and therapeutic treatment. CT scans can help detect abnormalities in the lungs that are characteristic of COVID-19, such as ground-glass opacities and consolidation. This research work proposes an Intuitionistic fuzzy (IF) edge detector for the segmentation of COVID-19 CT images. Intuitionistic fuzzy sets go beyond conventional fuzzy sets by incorporating an additional parameter, referred to as the hesitation degree or non-membership degree. This extra parameter enhances the ability to represent uncertainty more intricately in expressing the degree to which an element may or may not belong to a set. The IF edge detector generates proficient results, when compared with the traditional edge detection algorithms and is validated in terms of performance metrics for benchmark images. Intuitionistic fuzzy edge detection has been shown to be effective in handling uncertainty and imprecision in edge detection.

10.
Heliyon ; 10(4): e26363, 2024 Feb 29.
Artigo em Inglês | MEDLINE | ID: mdl-38420453

RESUMO

A gains optimizer of a fuzzy controller system for an Unmanned Aerial Vehicle (UAV) based on a metaheuristic algorithm is developed in the present investigation. The contribution of the work is the adjustment by the Genetic Algorithm (GA) to tune the gains at the input of a fuzzy controller. First, a typical fuzzy controller was modeled, designed, and implemented in a mathematical model obtained by Newton-Euler methodology. Subsequently, the control gains were optimized using a metaheuristic algorithm. The control objective is that the UAV consumes the least amount of energy. With this basis, the Genetic Algorithm finds the necessary gains to meet the design parameters. The tests were performed using the Matlab-Simulink environment. The results indicate an improvement, reducing the error in tracking trajectories from 30% in some tasks and following trajectories that could not be completed without a tuned controller in other tasks.

11.
Sensors (Basel) ; 24(4)2024 Feb 08.
Artigo em Inglês | MEDLINE | ID: mdl-38400256

RESUMO

For the precise measurement of complex surfaces, determining the position, direction, and path of a laser sensor probe is crucial before obtaining exact measurements. Accurate surface measurement hinges on modifying the overtures of a laser sensor and planning the scan path of the point laser displacement sensor probe to optimize the alignment of its measurement velocity and accuracy. This manuscript proposes a 3D surface laser scanning path planning technique that utilizes adaptive ant colony optimization with sub-population and fuzzy logic (SFACO), which involves the consideration of the measurement point layout, probe attitude, and path planning. Firstly, this study is based on a four-coordinate measuring machine paired with a point laser displacement sensor probe. The laser scanning four-coordinate measuring instrument is used to establish a coordinate system, and the relationship between them is transformed. The readings of each axis of the object being measured under the normal measuring attitude are then reversed through the coordinate system transformation, thus resulting in the optimal measuring attitude. The nominal distance matrix, which demonstrates the significance of the optimal measuring attitude, is then created based on the readings of all the points to be measured. Subsequently, a fuzzy ACO algorithm that integrates multiple swarm adaptive and dynamic domain structures is suggested to enhance the algorithm's performance by refining and utilizing multiple swarm adaptive and fuzzy operators. The efficacy of the algorithm is verified through experiments with 13 popular TSP benchmark datasets, thereby demonstrating the complexity of the SFACO approach. Ultimately, the path planning problem of surface 3D laser scanning measurement is addressed by employing the proposed SFACO algorithm in conjunction with a nominal distance matrix.

12.
MethodsX ; 12: 102580, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38322137

RESUMO

BACKGROUND: Indonesia is one of the coffee producers ranked third in the world in the supply of coffee beans. To maintain competitiveness international market, it is necessary to maintain and improve the quality of coffee beans. OBJECTIVE: One crucial aspect of maintaining the quality of coffee beans is maintaining the moisture content of green coffee beans. One of the water content settings is using the drying method. While traditional drying methods often experience weather and long-time constraints. RESULTS: This study designed an innovative coffee bean dryer based on fuzzy logic to overcome the problem. This system uses temperature control with Mamdani's fuzzy logic control interference algorithm, input and delta errors, and output percentage valve opening. This method achieved a moisture content following SNI standards of 12% and a 0.00015% / s drying rate for each coffee bean mass increased by 1kg. This method is also more efficient and stable in maintaining the temperature at a value of 50°C. METHODS: The drying equipment also estimates the drying time by considering variations in the mass of coffee beans. This dryer can provide an effective solution to maintain optimal coffee bean quality. CONCLUSION: The second semi-wash method of drying coffee beans using a fuzzy logic-based coffee bean drier has proven successful for drying coffee beans to a moisture content of 12% in a period of 90 min to 195.65 min with a drying capacity of 1 kilogram to 10kg at 50°C.•The coffee beans utilized in the studies are robusta coffee beans from plantations on Mount Kawi's slopes in East Java, Indonesia.•The trial sample was 1 kilogram of green coffee beans removed from the horn skin.•According to SNI standards, the drying performed is the second in the postharvest semi-wash procedure to achieve a moisture content of 12%.

13.
Biosystems ; 237: 105161, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38387806

RESUMO

The white potato worm (Premnotrypes Vorax (Hustache)) is one of the pests that causes the greatest damage to the potato crop and the greatest economic losses to the grower; therefore, knowing its life cycle and estimating its intrinsic growth rate is crucial for selecting an appropriate chemical control method, in order to reduce the environmental impact and ensure a profitable production suitable for consumption. In this article, we present a fuzzy Malthusian model describing the evolution of the white potato worm in the crop, considering that the intrinsic growth rate and the reported initial data on the problem are of fuzzy nature. The main contributions and novelty of this paper are summarized in the following two aspects: first, the estimation of the intrinsic growth rate of the white potato worm, in function of the temperature, by using a Takagi-Sugeno-Kang type fuzzy rule-based model; and second, since in practice the initial white potato worm population in a crop is subjective, imprecise and vague, knowing the intrinsic growth rate, we propose and solve a fuzzy initial value problem to determine the evolution in time of the white potato worm population. In conclusion, given a weekly average temperature, it is possible to know the white potato worm population per unit area oscillating in an interval whose length depends on the degree of inaccuracy of the initial population and the intrinsic growth rate. This study can be relevant for grower decision making in terms of the type and frequency of pest control on his crop.


Assuntos
Algoritmos , Lógica Fuzzy
14.
Math Biosci Eng ; 21(1): 474-493, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-38303431

RESUMO

In this work, we examine an adaptive and event-triggered distributed controller for nonlinear multi-agent systems (MASs). Second, we present a fuzzy adaptive event-triggered distributed control approach using a Lyapunov-based filter and the backstepping recursion technique. Next, the controller and adaptive rule presented guarantee that all tracking errors between the leader and the follower converge in a limited area close to the origin. According to the Lyapunov stability theory, this demonstrates that all other signals inside the closed loop are assured to be semi-globally, uniformly and finally constrained. Finally, simulation tests are conducted to illustrate the effectiveness of the control mechanism.

15.
Heliyon ; 10(4): e26273, 2024 Feb 29.
Artigo em Inglês | MEDLINE | ID: mdl-38384537

RESUMO

Canned food market demand has arisen due to the higher need for instant and ready-to-eat food. Food preservatives are often added to canned and processed foods to prolong their shelf life and help to sustain the quality, taste, color, and food texture. However, excessive usage of such food preservatives can lead to various diseases and health issues including palpitations, allergies, and cancer. Therefore, food preservative detection in food samples is essential for safe consumption and health well-being. This paper proposed a fuzzy logic framework to determine the safety of food products based on the concentration of sulphur dioxide (SD), benzoic acid (BA), and sorbic acid (SA) in five different food categories as referred to the Food Acts 1983 and Food Regulations 1985 in Malaysia. The fuzzy logic framework comprises of Mamdani inference system design with 90 fuzzy rules, 15 and 5 membership functions for both the input and output parameters respectively. 50 random values and 10 lab analysis results based on the industrial samples were used to validate the developed algorithms in ensuring the safety of the food products. The membership functions generated for the three inputs (SD, BA, and SA) during the fuzzification steps are based on the maximum allowable limit from the food acts. The defuzzification of fuzzy logic gave an average output value of 0.1565, 0.1350, 0.1150, 0.1100, and 0.1550 for chicken curry with potatoes, satay sauce, sardine in tomato sauce, anchovies paste, and sardine spread accordingly. Results obtained from the fuzzy logic framework concluded that all the industrial samples are safe to be eaten and comply with the Sixth Schedule, Regulation 20 in both Acts.

16.
Heliyon ; 10(4): e25731, 2024 Feb 29.
Artigo em Inglês | MEDLINE | ID: mdl-38390072

RESUMO

This study aims to quantitatively and qualitatively assess the impact of urbanisation on the urban ecosystem in the city of Abha, Saudi Arabia, by analysing land use changes, urbanisation processes and their ecological impacts. Using a multidisciplinary approach, a novel remote sensing-based urban ecological condition index (RSUSEI) will be developed and applied to assess the ecological status of urban surfaces. Therefore, the identification and quantification of urbanisation is important. To do so, we used hyper-tuned artificial neural network (ANN) as well as Land Cover Change Rate (LCCR), Land Cover Index (LCI) and Landscape Expansion Index (LEI). For the development of (RSUSEI), we have used four advanced models such as fuzzy Logic, Principle Component Analysis (PCA), Analytical Hierarchy Process (AHP) and fuzzy Analytical Hierarchy Process (FAHP) to integrate various ecological parameters. In order to obtain more information for better decision making in urban planning, sensitivity and uncertainty analyses based on a deep neural network (DNN) were also used. The results of the study show a multi-layered pattern of urbanisation in Saudi Arabian cities reflected in the LCCR, indicating rapid urban expansion, especially in the built-up areas with an LCCR of 0.112 over the 30-year period, corresponding to a more than four-fold increase in urban land cover. At the same time, the LCI shows a remarkable increase in 'built-up' areas from 3.217% to 13.982%, reflecting the substantial conversion of other land cover types to urban uses. Furthermore, the LEI emphasises the complexity of urban growth. Outward expansion (118.98 km2), Edge-Expansion (95.22 km2) and Infilling (5.00 km2) together paint a picture of a city expanding outwards while filling gaps in the existing urban fabric. The RSUSEI model shows that the zone of extremely poor ecological condition covers an area of 157-250 km2, while the natural zone covers 91-410 km2. The DNN based sensitivity analysis is useful to determine the optimal model, while the integrated models have lower input parameter uncertainty than other models. The results of the study have significant implications for the management of urban ecosystems in arid areas and the protection of natural habitats while improving the quality of life of urban residents. The RSUSEI model can be used effectively to assess urban surface ecology and inform urban management techniques.

17.
Bioengineering (Basel) ; 11(2)2024 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-38391626

RESUMO

Fuzzy Cognitive Maps (FCMs) have become an invaluable tool for healthcare providers because they can capture intricate associations among variables and generate precise predictions. FCMs have demonstrated their utility in diverse medical applications, from disease diagnosis to treatment planning and prognosis prediction. Their ability to model complex relationships between symptoms, biomarkers, risk factors, and treatments has enabled healthcare providers to make informed decisions, leading to better patient outcomes. This review article provides a thorough synopsis of using FCMs within the medical domain. A systematic examination of pertinent literature spanning the last two decades forms the basis of this overview, specifically delineating the diverse applications of FCMs in medical realms, including decision-making, diagnosis, prognosis, treatment optimisation, risk assessment, and pharmacovigilance. The limitations inherent in FCMs are also scrutinised, and avenues for potential future research and application are explored.

18.
Biomimetics (Basel) ; 9(2)2024 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-38392162

RESUMO

Teleoperated robots have attracted significant interest in recent years, and data gloves are one of the commonly used devices for their operation. However, existing solutions still encounter two challenges: the ways in which data gloves capture human operational intentions and achieve accurate mapping. In order to address these challenges, we propose a novel teleoperation method using data gloves based on fuzzy logic controller. Firstly, the data are collected and normalized from the flex sensors on data gloves to identify human manipulation intentions. Then, a fuzzy logic controller is designed to convert finger flexion information into motion control commands for robot arms. Finally, experiments are conducted to demonstrate the effectiveness and precision of the proposed method.

19.
Biomimetics (Basel) ; 9(2)2024 Feb 19.
Artigo em Inglês | MEDLINE | ID: mdl-38392167

RESUMO

This work highlights the relevant contribution of conformational stereoisomers to the complexity and functions of any molecular compound. Conformers have the same molecular and structural formulas but different orientations of the atoms in the three-dimensional space. Moving from one conformer to another is possible without breaking covalent bonds. The interconversion is usually feasible through the thermal energy available in ordinary conditions. The behavior of most biopolymers, such as enzymes, antibodies, RNA, and DNA, is understandable if we consider that each exists as an ensemble of conformers. Each conformational collection confers multi-functionality and adaptability to the single biopolymers. The conformational distribution of any biopolymer has the features of a fuzzy set. Hence, every compound that exists as an ensemble of conformers allows the molecular implementation of a fuzzy set. Since proteins, DNA, and RNA work as fuzzy sets, it is fair to say that life's logic is fuzzy. The power of processing fuzzy logic makes living beings capable of swift decisions in environments dominated by uncertainty and vagueness. These performances can be implemented in chemical robots, which are confined molecular assemblies mimicking unicellular organisms: they are supposed to help humans "colonise" the molecular world to defeat diseases in living beings and fight pollution in the environment.

20.
Sci Rep ; 14(1): 4963, 2024 02 29.
Artigo em Inglês | MEDLINE | ID: mdl-38424187

RESUMO

The success of screening programs depends to a large extent on the adherence of the target population, so it is therefore of fundamental importance to develop computer simulation models that make it possible to understand the factors that correlate with this adherence, as well as to identify population groups with low adherence to define public health strategies that promote behavioral change. Our aim is to demonstrate that it is possible to simulate screening adherence behavior using computer simulations. Three versions of an agent-based model are presented using different methods to determine the agent's individual decision to adhere to screening: (a) logistic regression; (b) fuzzy logic components and (c) a combination of the previous. All versions were based on real data from 271,867 calls for diabetic retinopathy screening. The results obtained are statistically very close to the real ones, which allows us to conclude that despite having a high degree of abstraction from the real data, the simulations are very valid and useful as a tool to support decisions in health planning, while evaluating multiple scenarios and accounting for emergent behavior.


Assuntos
Diabetes Mellitus , Retinopatia Diabética , Humanos , Simulação por Computador , Retinopatia Diabética/diagnóstico , Retinopatia Diabética/epidemiologia , Programas de Rastreamento/métodos , Lógica Fuzzy , Modelos Logísticos
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